Wash and cut the Brussel sprouts in half and remove outer leaves.
On a large rimmed baking sheet, toss Brussels sprouts with enough olive oil to coat, and add salt, pepper, garlic powder, onion powder and apple cider and mix well to coat evenly.
Roast Brussels sprouts for about 25 to 35 minutes, depending on the size.
Stir the Brussels sprouts even 10 minutes to ensure even roasting, until Brussels sprouts are fork tender.